1982.09--1987.08 南通醫學(xue)院醫療系醫學(xue)專業學(xue)習(本(ben)科)
1987.08--1993.09 南(nan)通(tong)醫學(xue)(xue)(xue)院(yuan)附屬(shu)醫院(yuan)心臟內(nei)科醫師(shi)(其間:1989.09--1992.07 南(nan)通(tong)醫學(xue)(xue)(xue)院(yuan)內(nei)科學(xue)(xue)(xue)專業學(xue)(xue)(xue)習,獲醫學(xue)(xue)(xue)碩士(shi)學(xue)(xue)(xue)位)
1993.09--1996.06 上海第二醫科大學內科學專業博士(shi)研究(jiu)生
1996.07--1998.11 上海鐵道(dao)大學附屬甘(gan)泉醫院心臟(zang)內科主治醫師
1998.11--2000.04 上海鐵道大學附屬(shu)甘(gan)泉醫(yi)院心臟內科副主任醫(yi)師
2000.04--2001.06 同濟(ji)大學附屬同濟(ji)醫(yi)(yi)院心臟(zang)內科(ke)副主任(ren)醫(yi)(yi)師
2001.06--2003.01 同(tong)濟大學附屬同(tong)濟醫院心(xin)臟(zang)內科副教授
2003.01--2008.12 同(tong)濟(ji)大(da)學(xue)附(fu)屬同(tong)濟(ji)醫(yi)院心(xin)臟內科主任醫(yi)師、教授、博士(shi)生導師 (其(qi)間:2007.04當選九(jiu)三學(xue)社(she)上(shang)海市委(wei)副主委(wei))
2008.12--2009.12 同濟大學醫學院副院長
2009.12--2010.11 同(tong)濟大學醫學院(yuan)副(fu)院(yuan)長(chang)、病(bing)理(li)學與病(bing)理(li)生理(li)學系(xi)主任(兼)
2010.11--2011.11 同濟大學(xue)(xue)醫學(xue)(xue)院副(fu)院長、病理(li)學(xue)(xue)與(yu)病理(li)生(sheng)理(li)學(xue)(xue)系主任(ren)(兼)、附屬(shu)東方醫院副(fu)院長(兼)
2011.11--2016.02 同濟(ji)大學醫學院副院長、病理生理學系主任(兼)、附屬東方醫院副院長(兼)、心律失(shi)常教育部重(zhong)點(dian)實驗室(同濟(ji)大學)主任(其間:2013.02當選第十二屆全國政(zheng)協委(wei)員;2015.12當選中(zhong)國科學院院士(shi))
2016.02--2016.11 同濟大學(xue)醫(yi)(yi)學(xue)院副院長、病(bing)理學(xue)與病(bing)理生理學(xue)系主任(ren)(ren)(兼)、附屬東方醫(yi)(yi)院副院長(兼)、心(xin)臟(zang)醫(yi)(yi)學(xue)部主任(ren)(ren)、心(xin)臟(zang)內(nei)科主任(ren)(ren)、心(xin)律失(shi)常(chang)診療中心(xin)主任(ren)(ren)
2016.11--2017.12 同濟(ji)大學(xue)醫(yi)學(xue)與(yu)生(sheng)命科(ke)學(xue)部(bu)(bu)主(zhu)任(ren)(ren)、病理(li)(li)學(xue)與(yu)病理(li)(li)生(sheng)理(li)(li)學(xue)系主(zhu)任(ren)(ren)(兼(jian)(jian))、附屬東方醫(yi)院(yuan)副院(yuan)長(chang)(兼(jian)(jian))、心(xin)臟醫(yi)學(xue)部(bu)(bu)主(zhu)任(ren)(ren)、心(xin)臟內科(ke)主(zhu)任(ren)(ren)、心(xin)律(lv)失常診療中心(xin)主(zhu)任(ren)(ren)
2017.12-- 同濟大學副校(xiao)長(chang)、醫學與生(sheng)命科學部(bu)主任(ren)(ren)(ren)、病理學與病理生(sheng)理學系(xi)主任(ren)(ren)(ren)(兼)、附屬東方(fang)醫院副院長(chang)(兼)、心(xin)臟醫學部(bu)主任(ren)(ren)(ren)、心(xin)臟內科主任(ren)(ren)(ren)、心(xin)律失常診療中心(xin)主任(ren)(ren)(ren)
2005年(nian)07月:上海社會主義學院培(pei)訓結業
2006年09月(yue):中(zhong)央社(she)會主義學(xue)院進修結業
2007年04月:中(zhong)國浦東干部學院研修結業
2007年(nian)09月:中共上海(hai)市委黨校培訓(xun)結業
2012年09月:中國(guo)井岡山干部學院(yuan)培訓結業
2004-2004:美國凱斯西儲大學附屬醫院(yuan)心臟內(nei)科客座(zuo)教授
2007-2009:同濟大(da)學附屬同濟醫院心臟內科主任
2009-:同(tong)濟(ji)大學附屬東方醫院心(xin)臟(zang)內科學科帶頭人(ren)
2008年起:同濟(ji)大學(xue)特聘教授
2015年12月(yue)7日(ri),當選中國科學院院士
1. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003; 299(5604): 251-254. (Corresponding Author)
2. Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, Liang B, Lin J, Liu Y, Liu B, Zhou Q, Zhang D, Wang R, Ma N, Su X, Niu K, Pei Y, Xu W, Chen Z, Wan H, Cui J, Barhanin J, Chen Y. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet. 2004; 75(5): 899-905. (Corresponding Author)
3. Yang YZ, Yang YQ, Liang B, Liu JQ, Li J, Grunnet M, Olesen SP, Rasmussen HB, Ellinor PT, Gao LJ, Lin XP, Li L, Wang L, Xiao JJ, Liu Y, Liu Y, Zhang SL, Liang DD, Peng LY, Jespersen T, Chen YH. Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet. 2010; 86(6): 872-880.(Corresponding Author)
4. Xiao J, Liang D, Chen YH. The genetics of atrial fibrillation: from the bench to the bedside. Annu Rev Genomics Hum Genet. 2011; 12(22): 73-96. (Corresponding Author)
5. Li J, Qi M, Li C, Shi D, Zhang D, Xie D, Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, Huang J, Peng L, Chen YH. Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Res. 2014; 24(8):977-93. (Corresponding author)
6. Li J, Li CM, Zhang DS, Shi D, Qi M, Feng J, Yuan TY, Xu XR, Liang DD, Xu L, Zhang H, Liu Y, Chen JJ, Ye JC, Jiang WF, Cui YY, Zhang YY, Peng LY, Zhuo ZN, Chen YH. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. Nature Communications. 2014; 5: 5177.(Corresponding author)
7. Li J, Xie DY, Huang J, Lv F, Shi D, Liu Y, Lin L, Geng L, Wu YF, Liang DD, Chen YH. Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels. Cir Res. 2015; 8; 116(10): 1655-9. (Corresponding author)
8. Yang Y, Liu Y, Dong X, Kuang Y, Lin J, Su X, Peng L, Jin Q, He Y, Liu B, Pan Z, Li L, Zhu Q, Lin X, Zhou Q, Pan Q, Eurlings PMH, Fei J, Wang Z, Chen YH. Human KCNQ1 S140G mutation is associated with atrioventricular blocks. Heart Rhythm. 2007; 4(5): 611-618. (Corresponding Author)
9. Volders PG, Zhu Q, Timmermans C, Eurlings PM, Su X, Arens YH, Li L, Jongbloed RJ, Xia M, Rodriguez LM, Chen YH. Mapping a novel locus for familial atrial fibrillation on chromosome 10p11-q21. Heart Rhythm. 2007; 4(4): 469-475. (Corresponding Author)
10. Li J, Xiao J, Liu Y, Zhang G, Zhang H, Liang D, Liu Y, Zhang Y, Hu Y, Yu Z, Yan B, Jiang B, Peng L, Zhou ZN, Chen YH. Mitochondrial benzodiazepine receptors mediate cardioprotection of estrogen against ischemic ventricular fibrillation. Pharmacol Res. 2009; 60(1): 61-67. (Corresponding Author)
11. Yang Y, Li J, Lin X, Yang Y, Hong K, Wang L, Liu J, Li L, Yan D, Liang D, Xiao J, Jin H, Wu J, Zhang Y, Chen YH. Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. J Hum Genet. 2009; 54(5): 277-283. (Corresponding Author)
12. Xiao JJ, Liang DD, Zhang H, Liu Y, Li FJ, Chen YH. 4’-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats. Exp Biol Med. 2010; 235(4): 478-486. (Corresponding Author)
13. Li J, Xiao JJ, Liang DD, Zhang H, Zhang GF, Liu Y, Zhang YY, Liu Y, Yu Z, Yan B, Jiang B, Li F, Peng LY, Zhou ZN, Chen YH. Inhibition of mitochondrial translocator protein prevents atrial fibrillation. Eur J Pharmacol. 2010; 632(1-3): 60-64. (Corresponding Author)
14. Li J, Yan B, Huo ZX, Liu Y, Xu JH, Sun YF, Liu Y, Liang DD, Peng LY, Zhang YY, Zhou ZN, Shi JY, Cui JM, Chen YH. Beta2- but not beta1-adrenoceptor activation modulates intracellular oxygen availability. J Physiol. 2010; 588(16): 2987-2998. (Corresponding Author)
15. Li J, Xu J, Xiao J, Zhang H, Liang D, Liu Y, Zhang Y, Liu Y, Wen W, Hu Y, Yu Z, Yan B, Jiang B, Zhou ZN, Chen YH. Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity. J Cell Mol Med. 2011; 15(1): 134-140. (Corresponding Author)
16. Yan B, Huo Z, Liu Y, Lin X, Li J, Peng L, Zhao H, Zhou ZN, Liang X, Liu Y, Zhu W, Liang D, Li L, Sun Y, Cui J, Chen YH. Prolyl hydroxylase 2: A novel regulator of β2-adrenoceptor internalization. J Cell Mol Med. 2011; 15(12): 2712-2722. (Corresponding Author)
17. Xiao J, Liang D, Zhang Y, Liu Y, Zhang H, Liu Y, Li L, Liang X, Sun Y, Chen YH. MicroRNA expression signature in atrial fibrillation with mitral stenosis. Physiol Genomics. 2011; 43(11): 655-664. (Corresponding Author)
18. Xiao J, Jing ZC, Ellinor PT, Liang D, Zhang H, Liu Y, Chen X, Pan L, Lyon R, Liu Y, Peng LY, Liang X, Sun Y, Popescu LM, Condorelli G, Chen YH. MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism. J Transl Med. 2011; 24(9): 159. (Corresponding Author)
19. Xiao JJ, Liang DD, Liu Y, Zhang H, Liu Y, Zhao H, Li J, Peng LY, Zhou ZN, Chen YH. Taxol, a microtubule stabiliser, improves cardiac functional recovery during post-ischaemic reperfusion in rat in vitro. Cardiovasc Ther. 2012; 30(1): 12-30 (Corresponding Author)
20. Xiao J, Liang D, Zhang H, Liu Y, Zhang D, Liu Y, Pan L, Chen X, Doevendans PA, Sun Y, Liang X, Sluijter JP, Chen YH. MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells. J Mol Cell Cardiol. 2012; 53(6): 751-759. (Corresponding Author)
21. Li J, Zhang DS, Ye JC, Li CM, Qi M, Liang D, Xu XR, Xu L, Liu Y, Zhang H, Zhang Y,Deng F, Feng J, Shi D, Chen J, Li L, Chen G, Sun YF, Peng LY, Chen YH. Dynamin-2 mediates heart failure by modulating Ca2+-dependent cardiomyocyte apoptosis. Int J Cardiol. 2013; 168(3): 2109-2119. (Corresponding Author)
22. Li J, Xu L, Ye J, Li X, Zhang D, Liang D, Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y, Zhang Y, Zhou Z, Liang X, Li J, Peng L, Zhu W, Chen YH. Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis. J Cell Mol Med. 2013; 17(9): 1119-1127. (Corresponding author)
23. Li X, Jiang XY, Ge J, Wang J, Chen GJ, Xu L, Xie DY, Yuan TY, Zhang DS, Chen YH. Aberrantly expressed lncRNAs in Primary Varicose Great Saphenous Veins. PLoS one. 2014; 9: e86156. (Corresponding author)
24. Liang D, Xu X, Deng F, Feng J, Zhang H, Liu Y, Zhang Y, Pan L, Liu Y, Zhang D, Li J, Liang X, Sun Y, Xiao J, Chen YH. miRNA-940 reduction contributes to human Tetralogy of Fallot development. J Cell Mol Med. 2014; 18(9): 1830-1839. (Corresponding author)
25. Liang D, Zhen L, Yuan T, Huang J, Deng F, Wuyahan, Zhang H, Pan L, Liu Y, The E, Yu Z, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. miR-10a Regulates Proliferation of Human Cardiomyocyte Progenitor Cells by Targeting GATA6. PLoS One. 2014; 9(7): e103097. (Corresponding author)
26. Shi D, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. J Cell Mol Med. 2014; 18(10): 1992-1999. (Corresponding author)
27. Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans SM. HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013; 113(4): 399-407.
28. Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nature Communications. 2013; 4: 2812.
29. Zhang G, Yang H, Liang H, Yang J, Shi J, McFarland K, Chen Y, Cui J. A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. J Neurosci. 2014; 34(37): 12280-8.
陳義(yi)漢教授長期從(cong)事心(xin)血管疾病(bing)臨床(chuang)(chuang)工作和(he)基礎研(yan)究,臨床(chuang)(chuang)特長為心(xin)律(lv)失常(chang)和(he)心(xin)力衰(shuai)竭的診斷和(he)治療,研(yan)究方向(xiang)為心(xin)律(lv)失常(chang)和(he)心(xin)力衰(shuai)竭的發(fa)生(sheng)機(ji)制(zhi)和(he)干預(yu)。在心(xin)律(lv)失常(chang)和(he)心(xin)力衰(shuai)竭研(yan)究領域取得(de)了一些(xie)重要的科(ke)學(xue)發(fa)現(xian)。
以(yi)通訊作者身份在中國(guo)本(ben)土上發(fa)(fa)表(biao)SCI論文近50篇,被SCI他(ta)引1000多次(ci)(ci),單篇SCI他(ta)引近500次(ci)(ci)。標志性成果發(fa)(fa)表(biao)在《Science》、《Nature Communications》、《Am J Hum Genet》、《Annu Rev Genomics Hum Genet》、《Cell Res》和《Circulation Research》等(deng)權威刊(kan)物上。他(ta)的(de)科(ke)(ke)學(xue)發(fa)(fa)現(xian)已經(jing)被寫(xie)進(jin)了50多本(ben)國(guo)外教科(ke)(ke)書和專著,國(guo)際診療指(zhi)南多次(ci)(ci)引用(yong)他(ta)的(de)工作,多種遺傳(chuan)性心(xin)律失常(chang)是依據他(ta)的(de)發(fa)(fa)現(xian)而分類。他(ta)的(de)科(ke)(ke)學(xue)發(fa)(fa)現(xian)也曾經(jing)被評為國(guo)際心(xin)臟電生(sheng)理學(xue)領域年(nian)度突破性進(jin)展和中國(guo)高等(deng)學(xue)校(xiao)十大(da)科(ke)(ke)技進(jin)展等(deng)。
2003年,陳義漢在國(guo)(guo)(guo)際(ji)上首次發現(xian)人類心(xin)(xin)房顫動致(zhi)病基因,鑒定出(chu)人類心(xin)(xin)房顫動的(de)部分遺傳學(xue)和(he)(he)電(dian)生理學(xue)機制,成果(guo)發表于(yu)《科學(xue)》雜(za)志。此(ci)后他帶領團(tuan)隊在心(xin)(xin)房顫動等心(xin)(xin)律失(shi)常的(de)機制和(he)(he)干預研究方向上取得一系(xi)列重要發現(xian),為(wei)中國(guo)(guo)(guo)在國(guo)(guo)(guo)際(ji)心(xin)(xin)律失(shi)常研究領域贏得了一席之地。
國(guo)(guo)家(jia)(jia)(jia)自(zi)然(ran)科(ke)(ke)學(xue)(xue)獎(jiang)(jiang)二等(deng)獎(jiang)(jiang)(第(di)一(yi)完成人(ren))(2005年(nian))、教育部自(zi)然(ran)科(ke)(ke)學(xue)(xue)獎(jiang)(jiang)一(yi)等(deng)獎(jiang)(jiang)(第(di)一(yi)完成人(ren))(2004年(nian))、上海(hai)市(shi)自(zi)然(ran)科(ke)(ke)學(xue)(xue)獎(jiang)(jiang)一(yi)等(deng)獎(jiang)(jiang)(第(di)一(yi)完成人(ren))(2011年(nian))、上海(hai)市(shi)自(zi)然(ran)科(ke)(ke)學(xue)(xue)牡丹(dan)獎(jiang)(jiang)(2009年(nian))、國(guo)(guo)家(jia)(jia)(jia)973計劃首席科(ke)(ke)學(xue)(xue)家(jia)(jia)(jia)(2012年(nian))、國(guo)(guo)家(jia)(jia)(jia)杰(jie)出(chu)青年(nian)科(ke)(ke)學(xue)(xue)基金獲(huo)(huo)得者(2004年(nian))、上海(hai)市(shi)領(ling)軍人(ren)才(cai)(cai)(2005年(nian))、中(zhong)國(guo)(guo)醫師獎(jiang)(jiang)(2006年(nian))、新(xin)世紀(ji)百千萬人(ren)才(cai)(cai)工(gong)程國(guo)(guo)家(jia)(jia)(jia)級人(ren)選(2006年(nian))、教育部創新(xin)團隊負(fu)責人(ren)(2007年(nian))、國(guo)(guo)家(jia)(jia)(jia)創新(xin)研究群體負(fu)責人(ren)(2012)、中(zhong)國(guo)(guo)青年(nian)科(ke)(ke)技獎(jiang)(jiang)(2005年(nian))、上海(hai)市(shi)優秀學(xue)(xue)科(ke)(ke)帶頭(tou)人(ren)(2005年(nian))、衛生部有突出(chu)貢獻(xian)的中(zhong)青年(nian)專家(jia)(jia)(jia)(2004年(nian))、上海(hai)市(shi)優秀專業(ye)技術人(ren)才(cai)(cai)(2003年(nian))、國(guo)(guo)務院特殊津貼獲(huo)(huo)得者(2004年(nian))、上海(hai)市(shi)勞動(dong)(dong)模范(2001-2003年(nian)度;2004-2006年(nian)度)、全國(guo)(guo)五一(yi)勞動(dong)(dong)獎(jiang)(jiang)章獲(huo)(huo)得者(2006年(nian))。
2020年2月(yue)19日(ri),入選國家(jia)健康科普專家(jia)庫。